Structure and Absolute Configuration of Diterpenoids from Hymenaea stigonocarpa

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• 作者：Afif F. Monteiro ; Jo茫o M. Batista ; Jr. ; Michelle A. Machado ; Richele P. Severino ; Ewan W. Blanch ; Vanderlan S. Bolzani ; Paulo C. Vieira ; Vanessa G. P. Severino
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：June 26, 2015
• 年：2015
• 卷：78
• 期：6
• 页码：1451-1455
• 全文大小：279K
• ISSN：1520-6025

文摘

Chemical investigations of the ethanolic extracts from the flowers and leaves of Hymenaea stigonocarpa Mart. ex Hayne afforded one new ent-halimane diterpenoid, 18-hydroxy-ent-halima-1(10),13-(E)-dien-15-oic acid (1), together with five known compounds (2鈥?b>6). The structural elucidation was performed by means of NMR (COSY, HSQC, HMBC, and NOESY) and MS analyses. Complete ¹H and ¹³C NMR data assignments are also reported for labd-13-en-8尾-ol-15-oic (2) and labd-7,13-dien-15-oic (3) acids. The absolute configurations of 1 and 2 were established by comparison of experimental and calculated Raman optical activity spectra.