Fabrication of Reduced Graphene Oxide and Sliver Nanoparticle Hybrids for Raman Detection of Absorbed Folic Acid: A Potential Cancer Diagnostic Probe

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• 作者：Chaofan Hu ; Yingliang Liu ; Jinlan Qin ; Guangting Nie ; Bingfu Lei ; Yong Xiao ; Mingtao Zheng ; Jianhua Rong
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2013
• 出版时间：June 12, 2013
• 年：2013
• 卷：5
• 期：11
• 页码：4760-4768
• 全文大小：509K
• 年卷期：v.5,no.11(June 12, 2013)
• ISSN：1944-8252

文摘

Reduced graphene oxide (RGO) and silver nanoparticle (AgNP) hybrids (RGO-AgNP) were prepared by a facile one-pot method using Poly (N-vinyl-2-pyrrolidone) as reductant and stabilizer. Folic acid (FA) molecules were attached to the RGO-AgNP by physisorption for targeting specific cancer cells with folate receptors (FRs) and using as Raman reporter molecules. The internalization of the FA loaded RGO-AgNP (RGO-AgNP-FA) inside the FRs-positive cancer cell was confirmed by confocal laser scanning and transmission electron microscopy. The Raman signals of the FA in live cancer cells were detected by confocal Raman spectroscope at 514 nm excitation, indicating that the RGO-AgNP-FA material has great potential as a Raman probe for cancer diagnosis in vitro.

Keywords:

graphene oxide; silver nanoparticle; folic acid; surface-enhanced Raman scattering; cancer; diagnosis