The First Total Synthesis of Nakadomarin A

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• 作者：Toshiaki Nagata ; Masako Nakagawa ; and Atsushi Nishida
• 刊名：Journal of the American Chemical Society
• 出版年：2003
• 出版时间：June 25, 2003
• 年：2003
• 卷：125
• 期：25
• 页码：7484 - 7485
• 全文大小：74K
• 年卷期：v.125,no.25(June 25, 2003)
• ISSN：1520-5126

文摘

(-)-Nakadomarin A is a member of manzamine alkaloid isolated from a marine sponge and have a unique hexacyclic structure. The first total synthesis of (+)-nakadomarin A, an enantiomer of natural product, has been accomplished from stereochemically defined 4-oxopiperidin-3-carboxylic acid derivative. The synthesis established the structure of nakadomarin A including absolute configuration.