Belizentrin, a Highly Bioactive Macrocycle from the Dinoflagellate Prorocentrum belizeanum

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• 作者：Humberto J. Dom铆nguez ; Jos茅 G. Napolitano ; M. Teresa Fern谩ndez-S谩nchez ; David Cabrera-Garc铆a ; Antonello Novelli ; Manuel Norte ; Jos茅 J. Fern谩ndez ; Antonio Hern谩ndez Daranas
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：September 5, 2014
• 年：2014
• 卷：16
• 期：17
• 页码：4546-4549
• 全文大小：305K
• ISSN：1523-7052

文摘

Belizentrin (1), a novel 25-membered polyketide-derived macrocycle, was isolated from cultures of the marine dinoflagellate Prorocentrum belizeanum. This metabolite is the first member of an unprecedented class of polyunsaturated and polyhydroxylated macrolactams. The structure of 1 was primarily determined by NMR and computational methods. Pharmacological assays with cerebellar cells showed that 1 produces important changes in neuronal network integrity at nanomolar concentrations.