Design of a Numbering-up System of Monolithic Microreactors and Its Application to Synthesis of a Key Intermediate of Valsartan

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• 作者：Aiichiro Nagaki ; Katsuyuki Hirose ; Osamu Tonomura ; Satoshi Taniguchi ; Toshiki Taga ; Shinji Hasebe ; Norio Ishizuka ; Jun-ichi Yoshida
• 刊名：Organic Process Research & Development
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：20
• 期：3
• 页码：687-691
• 全文大小：354K
• ISSN：1520-586X

文摘

Synthesis of a key intermediate of valsartan was accomplished using five parallel monolithic microreactors connected to a split-and-recombine-type flow distributor. The channel resistances of the flow distributor were designed so as to minimize the flow maldistribution among reactors by using pressure drop compartment model, which is analogous to electrical resistance network.