Rhodium(III)-Catalyzed Direct Cyanation of Aromatic C鈥揌 Bond to Form 2-(Alkylamino)benzonitriles Using N-Nitroso As Directing Group

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• 作者：Jiawei Dong ; Zhongjie Wu ; Zhengyi Liu ; Ping Liu ; Peipei Sun
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：80
• 期：24
• 页码：12588-12593
• 全文大小：394K
• ISSN：1520-6904

文摘

2-(Alkylamino)benzonitriles were synthesized via a rhodium-catalyzed cyanation on the aryl C鈥揌 bond and subsequent denitrosation of N-nitrosoarylamines using a removable nitroso as the directing group, in which N-cyano-N-phenyl-p-methylbenzenesulfonamide (NCTS) was used as the 鈥淐N鈥?source. Various substituents on the aryl ring and amino group of N-nitrosoarylamines tolerated the reaction, and the corresponding products were achieved in moderate to good yields.