Sulfonamide-Bridged Nucleic Acid: Synthesis, High RNA Selective Hybridization, and High Nuclease Resistance

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• 作者：Yasunori Mitsuoka ; Yuko Fujimura ; Reiko Waki ; Akira Kugimiya ; Tsuyoshi Yamamoto ; Yoshiyuki Hari ; Satoshi Obika
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 7, 2014
• 年：2014
• 卷：16
• 期：21
• 页码：5640-5643
• 全文大小：299K
• ISSN：1523-7052

文摘

2鈥?N,4鈥?C-(N-Methylamino)sulfonylmethylene-bridged thymidine (SuNA), which has a six-membered linkage including a sulfonamide moiety, was synthesized and introduced into oligonucleotides. The oligonucleotides containing SuNA exhibited excellent nuclease resistance, a high affinity toward single-stranded RNA, and a low affinity toward single-stranded DNA compared to the natural oligonucleotide.