Rapid Synthesis of Pharmaceutical Oxidation Products Using Electrochemistry: A Systematic Study of N-Dealkylation Reactions of Fesoterodine Using a Commercially Available Synthesis Cell

详细信息    查看全文

• 作者：Susana Torres ; Roland Brown ; Roman Szucs ; Joel M. Hawkins ; Garry Scrivens ; Alan Pettman ; Debbie Kraus ; Mark R. Taylor
• 刊名：Organic Process Research & Development
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：19
• 期：11
• 页码：1596-1603
• 全文大小：409K
• ISSN：1520-586X

文摘

A new method for the fast and convenient synthesis of pharmaceutical oxidation products is described. Two oxidation products of fesoterodine were electrochemically synthesized, isolated, and characterized. The influence of synthetic operating parameters such as pH, percentage of organic solvent in diluent, initial electrolyte concentration, and substrate concentration on the oxidation product profile was investigated. This synthetic procedure proved to be rapid, clean, and efficient compared to traditional synthetic methods and may be particularly useful for generating milligram quantities of reference samples of degradation products used as markers in chromatographic methods.