Indium Tri(isopropoxide)-Catalyzed Selective Meerwein鈥揚onndorf鈥揤erley Reduction of Aliphatic and Aromatic Aldehydes

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• 作者：Jaeyoung Lee ; Taekyu Ryu ; Sangjune Park ; Phil Ho Lee
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：77
• 期：10
• 页码：4821-4825
• 全文大小：248K
• 年卷期：v.77,no.10(May 18, 2012)
• ISSN：1520-6904

文摘

Indium tri(isopropoxide)-catalyzed Meerwein鈥揚onndorf鈥揤erley reduction of aliphatic and aromatic aldehydes in 2-propanol gave selectively the corresponding primary alcohols in good to excellent yields at room temperature. A wide range of functional groups including alkene, ether, ketone, ester, nitrile, and nitro were tolerated under the optimum reaction conditions. Chemoselective reductions were also achieved not only between aromatic aldehyde, aromatic ketone, and epoxide but also between aliphatic aldehyde and alkene.