Self-Assembly of a Catalytic Multivalent Peptide鈥揘anoparticle Complex

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• 作者：Davide Zaramella ; Paolo Scrimin ; Leonard J. Prins
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：May 23, 2012
• 年：2012
• 卷：134
• 期：20
• 页码：8396-8399
• 全文大小：271K
• 年卷期：v.134,no.20(May 23, 2012)
• ISSN：1520-5126

文摘

Catalytically active peptide鈥搉anoparticle complexes were obtained by assembling small peptide sequences on the surface of cationic self-assembled monolayers on gold nanoparticles. When bound to the surface, the peptides accelerate the transesterification of the p-nitrophenyl ester of N-carboxybenzylphenylalanine by more than 2 orders of magnitude. The gold nanoparticle serves as a multivalent scaffold for bringing the catalyst and substrate into close proximity but also creates a local microenvironment that further enhances the catalysis. The supramolecular nature of the ensemble permits the catalytic activity of the system to be modulated in situ.