High-Throughput Optimization of Ir-Catalyzed C鈥揌 Borylation: A Tutorial for Practical Applications

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• 作者：Sean M. Preshlock ; Behnaz Ghaffari ; Peter E. Maligres ; Shane W. Krska ; Robert E. Maleczka ; Jr. ; Milton R. Smith ; III
• 刊名：The Journal of the American Chemical Society
• 出版年：2013
• 出版时间：May 22, 2013
• 年：2013
• 卷：135
• 期：20
• 页码：7572-7582
• 全文大小：622K
• 年卷期：v.135,no.20(May 22, 2013)
• ISSN：1520-5126

文摘

With the aid of high-throughput screening, the efficiency of Ir-catalyzed C鈥揌 borylations has been assessed as functions of precatalyst, boron reagent, ligand, order of addition, temperature, solvent, and substrate. This study not only validated some accepted practices but also uncovered unconventional conditions that were key to substrate performance. We anticipate that insights drawn from these findings will be used to design reaction conditions for substrates whose borylations are difficult to impossible using standard catalytic conditions.