Preparation of Optically Pure Tertiary Phosphine Oxides via the Addition of P-Stereogenic Secondary Phosphine Oxide to Activated Alkenes

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• 作者：Ji-Ping Wang ; Shao-Zhen Nie ; Zhong-Yang Zhou ; Jing-Jing Ye ; Jing-Hong Wen ; Chang-Qiu Zhao
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：81
• 期：17
• 页码：7644-7653
• 全文大小：433K
• 年卷期：0
• ISSN：1520-6904

文摘

Functionalized P,C-stereogenic tertiary phosphine oxides were prepared by the addition of (R_P)-menthyl phenylphosphine oxide to activated olefins, in high dr_P and dr_C, and were isolated in excellent yields. The reaction was readily catalyzed by Ca(OH)₂ or occurred with gentle heating. A wide range of substrates, including vinyl ketones, esters, nitriles, and nitro alkenes, can be used in the reaction.