Polycycloiridals with a Cyclopentane Ring from Iris tectorum

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• 作者：Chun-Lei Zhang ; Zhi-You Hao ; Yan-Fei Liu ; Yan Wang ; Guo-Ru Shi ; Zhi-Bo Jiang ; Ruo-Yun Chen ; Zheng-Yu Cao ; De-Quan Yu
• 刊名：Journal of Natural Products
• 出版年：2017
• 出版时间：January 27, 2017
• 年：2017
• 卷：80
• 期：1
• 页码：156-161
• 全文大小：375K
• ISSN：1520-6025

文摘

Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E–J (1–6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC₅₀ value of 0.54 μM.