Fluorescence Turn-On Chemosensor for Highly Selective and Sensitive Detection and Bioimaging of Al3+ in Living Cells Based on Ion-Induced Aggregation

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• 作者：Shilang Gui ; Yanyan Huang ; Fang Hu ; Yulong Jin ; Guanxin Zhang ; Liushui Yan ; Deqing Zhang ; Rui Zhao
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：February 3, 2015
• 年：2015
• 卷：87
• 期：3
• 页码：1470-1474
• 全文大小：282K
• ISSN：1520-6882

文摘

Herein, a new fluorescence turn-on chemosensor 2-(4-(1,2,2-triphenylvinyl)phenoxy)acetic acid (TPE-COOH) specific for Al³⁺ was presented by combining the aggregation-induced-emission (AIE) effect of tertaphenylethylene and the complexation capability of carboxyl. The introduction of carboxylic group provides the probe with good water-solubility which is important for analyzing biological samples. The recognition toward Al³⁺ induced the molecular aggregation and activated the blue fluorescence of the TPE core. The high selectivity of the probe was demonstrated by discriminating Al³⁺ over a variety of metal ions in a complex mixture. A detection limit down to 21.6 nM was determined for Al³⁺ quantitation. Furthermore, benefiting from its good water solubility and biocompatibility, imaging detection and real-time monitoring of Al³⁺ in living HeLa cells were successfully achieved. The AIE effect of the probe enables high signal-to-noise ratio for bioimaging even without multiple washing steps. These superiorities make this probe a great potential for the functional study and analysis of Al³⁺ in complex biosystems.