3-Aminoquinazolinediones as a New Class of Antibacterial Agents Demonstrating Excellent Antibacterial Activity Against Wild-Type and Multidrug Resistant Organisms

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• 作者：Edmund L. Ellsworth ; Tuan P. Tran ; H. D. Hollis Showalter ; Joseph P. Sanchez ; Brian M. Watson ; Michael A. Stier ; John M. Domagala ; Stephen J. Gracheck ; E. Themis Joannides ; Martin A. Shapiro ; Steve A.
• 刊名：Journal of Medicinal Chemistry
• 出版年：2006
• 出版时间：November 2, 2006
• 年：2006
• 卷：49
• 期：22
• 页码：6435 - 6438
• 全文大小：48K
• 年卷期：v.49,no.22(November 2, 2006)
• ISSN：1520-4804

文摘

The 3-aminoquinzolinediones represent a new series ofantibacterial agents structurally related to the fluoroquinolones. Theyare inhibitors of bacterial gyrase and topoisomerase IV and demonstrateclinically useful antibacterial activity against fastidious Gram-negativeand Gram-positive organisms, including multidrug- and fluoroquinolone-resistant organisms. These agents also demonstrate in vivo efficacyin murine systemic infection models.