Dahurelmusin A, a Hybrid Peptide–Polyketide from Elymus dahuricus Infected by the Epichloë bromicola Endophyte

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• 作者：Qiu-Yan SongHai-Tao Yu ; Xing-Xu Zhang ; Zhi-Biao Nan ; Kun Gao
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：298-300
• 全文大小：245K
• ISSN：1523-7052

文摘

One novel hybrid peptide–polyketide, dahurelmusin A (1), was isolated from Elymus dahuricus infected by the Epichloë bromicola endophyte. Comprehensive spectroscopic analysis revealed that 1 is the first example of hybrid peptide–polyketide possessing an unprecedented 5-hydroxy-2,2,4,6-tetramethyl-3-oxooctanoic acid moiety. The single-crystal X-ray diffraction analyses allowed the absolute configuration assignment of this compound. Compound 1 also exhibited significant insecticidal activities against Rhopalosiphum padi and Brevicoryne brassicae with LC₅₀ values of 0.092 and 0.251 mM, respectively.