Enantioselective Rh-Catalyzed Domino Transformations of Alkynylcyclohexadienones with Organoboron Reagents

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• 作者：Juliane Keilitz ; Stephen G. Newman ; Mark Lautens
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：March 1, 2013
• 年：2013
• 卷：15
• 期：5
• 页码：1148-1151
• 全文大小：272K
• 年卷期：v.15,no.5(March 1, 2013)
• ISSN：1523-7052

文摘

A new enantioselective rhodium-catalyzed domino reaction is described that gives access to fused heterocycles by desymmetrization of alkyne-tethered cyclohexadienones. Two new C鈥揅 bonds and two stereocenters are formed in one step with good enantioselectivity. In contrast to prior reports, it was found that a vinylidene is not involved in the product formation but that syn-addition of the rhodium-aryl species onto the alkyne takes place.