Micro/Nanostructured Hyaluronic Acid Matrices with Tuned Swelling and Drug Release Properties

详细信息    查看全文

• 作者：Yanina Minaberry ; Diego A. Chiappetta ; Alejandro Sosnik ; Mat铆as Jobb谩gy
• 刊名：Biomacromolecules
• 出版年：2013
• 出版时间：January 14, 2013
• 年：2013
• 卷：14
• 期：1
• 页码：1-9
• 全文大小：550K
• 年卷期：v.14,no.1(January 14, 2013)
• ISSN：1526-4602

文摘

Hyaluronic acid (HA) hydrogels were structured in the form of porous monoliths by means of the ice-segregation-induced self-assembly (ISISA) method coupled with freeze鈥揹rying. Physical and chemical parameters were explored in order to fine-tune the microstructure and the incidence on both swelling and dissolution behavior in aqueous media. Gentamicin-loaded HA matrices with tuned drug release properties were also prepared; their inherent properties and behavior in solution are discussed in the framework of thermal analysis and scanning electron microscopy inspection.