5鈥?Guanosine Monophosphate Mediated Biocompatible Porous Hydrogel of 尾-FeOOH鈥擵iscoelastic Behavior, Loading, and Release Capabilities of Freeze-Dried Gel

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• 作者：Anil Kumar ; Sudhir Kumar Gupta
• 刊名：Journal of Physical Chemistry B
• 出版年：2014
• 出版时间：September 4, 2014
• 年：2014
• 卷：118
• 期：35
• 页码：10543-10551
• 全文大小：672K
• ISSN：1520-5207

文摘

The present manuscript reports the characterization, optimization of rheological properties, and loading and release capabilities of 5鈥?GMP mediated 尾-FeOOH hydrogel. Circular dichroism (CD) analysis indicates it to contain mainly the left-handed helix similar to that of Z-DNA. The highest viscosity (>300 cP) corresponds to the sample containing 2.5 脳 10^鈥? mol dm^鈥? of 5鈥?GMP (SP2H). Field emission scanning electron microscope (FESEM) and transmission electron microscope (TEM) studies indicate the freeze-dried (FD) SP2H to be porous in nature, which is also supported by its high Brunauer鈥揈mmett鈥揟eller (BET) surface area of 226 m²/g as compared to that of SP3H (75 m²/g). Selected area electron diffraction (SAED) analysis and Raman spectroscopy show it to contain 尾-FeOOH phase. The FD SP2H exhibits the high swelling ratio (326%) and loading capacity for methylene blue (MB) dye. It displays a controlled and efficient release (>90%) for optimized [MB] (2.5 脳 10^鈥? mol dm^鈥?) in 48 h. The low toxicity of as synthesized FD SP2H nanostructures against MDA-MB-231 (breast cancer cells) up to 100 渭g/mL suggests its biocompatible nature. The high porosity, surface area, % swelling, and loading and release performance of the hydrogel indicate its potential for drug delivery and other biological applications.