Magnetic Multilamellar Liposomes Produced by In Situ Synthesis of Iron Oxide Nanoparticles: “Magnetonions”

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• 作者：Chrystel Faure ; Marie-Edith Meyre ; Sylvain Trpout ; Olivier Lambert ; Eric Lebraud
• 刊名：Journal of Physical Chemistry B
• 出版年：2009
• 出版时间：June 25, 2009
• 年：2009
• 卷：113
• 期：25
• 页码：8552-8559
• 全文大小：353K
• 年卷期：v.113,no.25(June 25, 2009)
• ISSN：1520-5207

文摘

We report the formation of magnetic onion-type multilamellar vesicles. Iron oxide nanoparticles (np’s) were synthesized inside lipidic multilamellar vesicles by coprecipitation of vesicle-encapsulated Fe²⁺ and Fe³⁺ ions induced by HO⁻ diffusion through vesicle lamellae. The iron ion encapsulation efficiency of onions was measured by potentiometry and UV−vis absorbance spectroscopy. Its high value (75 ± 5% for both Fe²⁺ and Fe³⁺) ensures an intravesicular synthesis, as confirmed by cryo-transmission electron microscopy (TEM) imaging. The as-grown nanoparticles are characterized by X-ray diffraction analysis and TEM, and magnetic onions are imaged by cryo-TEM. The np size, controlled by temperature and time, ranges from 3 to 6 nm and is shown to be a key parameter for onion stability.