Selective ortho-Bromination of Substituted Benzaldoximes Using Pd-Catalyzed C鈥揌 Activation: Application to the Synthesis of Substituted 2-Bromobenzaldehydes

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• 作者：Emmanuelle Dubost ; Christine Fossey ; Thomas Cailly ; Sylvain Rault ; Frederic Fabis
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 5, 2011
• 年：2011
• 卷：76
• 期：15
• 页码：6414-6420
• 全文大小：809K
• 年卷期：v.76,no.15(August 5, 2011)
• ISSN：1520-6904

文摘

Substituted 2-bromobenzaldehydes were synthesized from benzaldehydes using a three-step sequence involving a selective palladium-catalyzed ortho-bromination as the key step. O-Methyloxime serves as a directing group in this reaction. A rapid deprotection of substituted 2-bromobenzaldoximes afforded substituted 2-bromobenzaldehydes with good overall yields.