Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells

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• 作者：Shuwei Zhang ; Rashmi Adhikari ; Mingxi Fang ; Nethaniah Dorh ; Cong Li ; Meghnath Jaishi ; Jingtuo Zhang ; Ashutosh Tiwari ; Ranjit Pati ; Fen-Tair Luo ; Haiying Liu
• 刊名：ACS Sensor
• 出版年：2016
• 出版时间：December 23, 2016
• 年：2016
• 卷：1
• 期：12
• 页码：1408-1415
• 全文大小：600K
• ISSN：2379-3694

文摘

We report two new near-infrared fluorescent probes based on Rhodol counterpart fluorophore platforms functionalized with dipicolylamine Zn(II)-binding groups. The combinations of the pendant amines and fluorophores provide the probes with an effective three-nitrogen-atom and one-oxygen-atom binding motif. The fluorescent probes with large Stokes shifts offer sensitive and selective florescent responses to Zn(II) ions over other metal ions, allowing a reversible monitoring of Zn(II) concentration changes in living cells, and detecting intracellular Zn(II) ions released from intracellular metalloproteins.