Biocompatible Hollow Polydopamine Nanoparticles Loaded Ionic Liquid Enhanced Tumor Microwave Thermal Ablation in Vivo

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• 作者：Longfei Tan ; Wenting Tang ; Tianlong Liu ; Xiangling Ren ; Changhui Fu ; Bo Liu ; Jun Ren ; Xianwei Meng
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2016
• 出版时间：May 11, 2016
• 年：2016
• 卷：8
• 期：18
• 页码：11237-11245
• 全文大小：667K
• 年卷期：0
• ISSN：1944-8252

文摘

Tumor microwave thermal therapy (MWTT) has attracted more attention because of the minimal damage to body function, convenient manipulation and low complications. Herein, a novel polydopamine (PDA) nanoparticle loading ionic liquids (ILs/PDA) as microwave susceptible agent is introduced for enhancing the selectivity and targeting of MWTT. ILs/PDA nanocomposites have an excellent microwave heating efficiency under an ultralow microwave power irradiation. Encouraging antitumor effect was observed when tumor bearing mice received ILs/PDA nanoparticles by intravenous injection and only single microwave irradiation. PDA nanoparticles with gold nanoparticles in core were constructed for tumor targeting study by ICP-MS and about 15% PDA nanoparticles were founded in tumor. Furthermore, the cytotoxicity and acute toxicity study in vivo of PDA showed the excellent biocompatibility of ILs/PDA nanocomposites. In addition, the degradation of ILs/PDA nanocomposites in simulated body fluid illustrated the low potential hazard when they entered the blood. The emergence of PDA as a novel and feasible platform for cancer thermal therapy will promote the rapid development of microwave therapy in clinics.