Lipodiscamides A鈥揅, New Cytotoxic Lipopeptides from Discodermia kiiensis

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• 作者：Karen Co Tan ; Toshiyuki Wakimoto ; Ikuro Abe
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：16
• 期：12
• 页码：3256-3259
• 全文大小：264K
• 年卷期：v.16,no.12(June 20, 2014)
• ISSN：1523-7052

文摘

Lipodiscamides A鈥揅, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and noncanonical amino acids, l-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and d-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.