Potent Airway Smooth Muscle Relaxant Effect of Cynatratoside B, a Steroidal Glycoside Isolated from Cynanchum stauntonii

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• 作者：Grace Gar-Lee Yue ; Kar-Man Chan ; Ming-Ho To ; Ling Cheng ; Kwok-Pui Fung ; Ping-Chung Leung ; Clara Bik-San Lau
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：April 25, 2014
• 年：2014
• 卷：77
• 期：4
• 页码：1074-1077
• 全文大小：218K
• 年卷期：v.77,no.4(April 25, 2014)
• ISSN：1520-6025

文摘

The dried roots of Cynanchum stauntonii in having cough-relieving efficacy are commonly included in traditional antitussive formulas. The active components in a C. stauntonii root extract responsible for airway relaxation were isolated using an ex vivo bioassay-guided fractionation method, in which subfractions were evaluated for their inhibitory effects on the contraction of isolated rat tracheal rings by isometric tension measurements. A steroidal glycoside, cynatratoside B (1), identified by LC-MS and NMR spectroscopic analysis, was shown to have potent inhibition on acetylcholine- and carbachol-induced tracheal contractions. The present data provide scientific evidence to support the traditional use of C. stauntonii as an antitussive herbal medicine.