Hybrid Nanotrimers for Dual T1 and T2-Weighted Magnetic Resonance Imaging

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• 作者：Kai Cheng ; Meng Yang ; Ruiping Zhang ; Chunxia Qin ; Xinhui Su ; Zhen Cheng
• 刊名：ACS Nano
• 出版年：2014
• 出版时间：October 28, 2014
• 年：2014
• 卷：8
• 期：10
• 页码：9884-9896
• 全文大小：833K
• ISSN：1936-086X

文摘

Development of multifunctional nanoparticle-based probes for dual T₁- and T₂-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T₁ and T₂- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Their potential as dual contrast agents for T₁ and T₂-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.

Keywords:

hybrid; nanotrimers; dumbbell structures; T₁/T₂-weighted magnetic resonance imaging; positron emission tomography