Triazole-Linked Glycolipids Enhance the Susceptibility of MRSA to 尾-Lactam Antibiotics

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• 作者：Xi-Le Hu ; Dan Li ; Lei Shao ; Xiaojing Dong ; Xiao-Peng He ; Guo-Rong Chen ; Daijie Chen
• 刊名：ACS Medicinal Chemistry Letters
• 出版年：2015
• 出版时间：July 9, 2015
• 年：2015
• 卷：6
• 期：7
• 页码：793-797
• 全文大小：297K
• ISSN：1948-5875

文摘

We show here that a series of triazolyl glycolipid derivatives modularly synthesized by a 鈥渃lick鈥?reaction have the ability to increase the susceptibility of a drug-resistant bacterium to 尾-lactam antibiotics. We determine that the glycolipids can suppress the minimal inhibitory concentration of a number of ineffective 尾-lactams, upward of 256-fold, for methicillin-resistant Staphylococuss aureus (MRSA). The mechanism of action has been preliminarily probed and discussed.