Chiral N,N′-Dioxide/Lanthanide(III) Complex Catalyzed Asymmetric Bisvinylogous Mukaiyama Aldol Reactions

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• 作者：Kai Fu ; Jingchuan Zhang ; Lili Lin ; Jun Li ; Xiaohua Liu ; Xiaoming Feng
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：19
• 期：2
• 页码：332-335
• 全文大小：424K
• ISSN：1523-7052

文摘

Chiral N,N′-dioxide/Y(OTf)₃ and Sc(OTf)₃ complexes have been developed as efficient catalysts for the bisvinylogous Mukaiyama aldol reaction of silyl ketene acetal with α-ketoesters and aldehydes, respectively. The catalytic systems were highly ε-selective, and the substrate scope was wide. The corresponding ε-hydroxy-α,β,γ,δ-unsaturated esters were obtained in up to 95% yield and 98% ee.