A Facile Preparation of an Octahydropyrrolo[2,3-c]pyridine Enantiomer

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• 作者：Wen-Chung Shieh ; Guang-Pei Chen ; Song Xue ; Joseph McKenna ; Xinglong Jiang ; Kapa Prasad ; Oljan Repi//pubs.acs.org/images/entities/ccaron.gif" border="0"> ; Christopher Straub ; Sushil K. Sh
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：11
• 期：4
• 页码：711 - 715
• 全文大小：92K
• 年卷期：v.11,no.4(July 2007)
• ISSN：1520-586X

文摘

A facile synthesis of octahydro-pyrrolo[2,3-c]pyridine 1 usingan intramolecular [3+2]-cycloaddition of an azomethine ylideas the key step and employing DW-therm heat-transfer fluidas a solvent is disclosed. Enantiomerically pure 1 was obtainedeither via a chromatographic separation of the diastereoisomers12 and 13 resulting from the cycloaddition with a chiralappendage or by a classical resolution of racemate 19.