Efficient and Selective Synthesis of (E)-Enamides via Ru(II)-Catalyzed Hydroamidation of Internal Alkynes

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• 作者：Changsheng Kuai ; Lianhui Wang ; Haoyi Cui ; Jinhai Shen ; Yadong Feng ; Xiuling Cui
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：January 4, 2016
• 年：2016
• 卷：6
• 期：1
• 页码：186-190
• 全文大小：454K
• ISSN：2155-5435

文摘

An efficient hydroamidation of benzylamides with internal alkynes catalyzed by Ru(II) has been developed. Various (E)-enamides were afforded in up to 95% yield for 28 examples. The protocol features excellent regio- and stereoselectivity, widely functional group tolerance, and easily accessible starting materials.