A Large Capacity Cationic Metal–Organic Framework Nanocarrier for Physiological pH Responsive Drug Delivery

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• 作者：Yanyu Yang ; Quan Hu ; Qi Zhang ; Ke Jiang ; Wenxin Lin ; Yu Yang ; Yuanjing Cui ; Guodong Qian
• 刊名：Molecular Pharmaceutics
• 出版年：2016
• 出版时间：August 1, 2016
• 年：2016
• 卷：13
• 期：8
• 页码：2782-2786
• 全文大小：301K
• 年卷期：0
• ISSN：1543-8392

文摘

A nanoscale cationic porous drug carrier ZJU-101 (ZJU = Zhejiang University), synthesized by the solvothermal method to get the crystal size of ∼300 nm, was used to load diclofenac sodium, an anionic drug. This positively charged host materials showed a large loading capacity of diclofenac sodium (∼0.546 g/g) through ion exchange and penetration procedures. The drug delivery in the inflamed tissues (pH = 5.4) exhibited a more effective release in comparison with that in the normal tissues (pH = 7.4), demonstrating a physiological pH responsive drug release. This discriminating drug release process was controlled by anion exchange between anions in phosphate buttered saline (PBS) and coordinated/free diclofenac anions.