Asperterpenols A and B, New Sesterterpenoids Isolated from a Mangrove Endophytic Fungus Aspergillus sp. 085242

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• 作者：Ze鈥檈n Xiao ; Huarong Huang ; Changlun Shao ; Xuekui Xia ; Lin Ma ; Xishan Huang ; Yongjun Lu ; Yongcheng Lin ; Yuhua Long ; Zhigang She
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：May 17, 2013
• 年：2013
• 卷：15
• 期：10
• 页码：2522-2525
• 全文大小：217K
• 年卷期：v.15,no.10(May 17, 2013)
• ISSN：1523-7052

文摘

Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures were elucidated on the basis of spectroscopic methods and the absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 and 2 inhibit acetylcholinesterase with IC₅₀ values of 2.3 and 3.0 渭M, respectively.