Water-Dispersible Ferrimagnetic Iron Oxide Nanocubes with Extremely High r2 Relaxivity for Highly Sensitive in Vivo MRI of Tumors

详细信息    查看全文

• 作者：Nohyun Lee ; Yoonseok Choi ; Youjin Lee ; Mihyun Park ; Woo Kyung Moon ; Seung Hong Choi ; Taeghwan Hyeon
• 刊名：Nano Letters
• 出版年：2012
• 出版时间：June 13, 2012
• 年：2012
• 卷：12
• 期：6
• 页码：3127-3131
• 全文大小：357K
• 年卷期：v.12,no.6(June 13, 2012)
• ISSN：1530-6992

文摘

The theoretically predicted maximum r₂ relaxivity of iron oxide nanoparticles was achieved by optimizing the overall size of ferrimagnetic iron oxide nanocubes. Uniform-sized iron oxide nanocubes with an edge length of 22 nm, encapsulated with PEG-phospholipids (WFION), exhibited high colloidal stability in aqueous media. In addition, WFIONs are biocompatible and did not affect cell viability at concentrations up to 0.75 mg Fe/ml. Owing to the enhanced colloidal stability and the high r₂ relaxivity (761 mM^鈥? s^鈥?), it was possible to successfully perform in vivo MR imaging of tumors by intravenous injection of 22-nm-sized WFIONs, using a clinical 3-T MR scanner.

Keywords:

Nanoparticle; nanomedicine; iron oxide; magnetic resonance imaging; contrast agent; colloidal stability