Axon-First Neuritogenesis on Vertical Nanowires

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• 作者：Kyungtae Kang ; Yi-Seul Park ; Matthew Park ; Min Jee Jang ; Seong-Min Kim ; Juno Lee ; Ji Yu Choi ; Da Hee Jung ; Young-Tae Chang ; Myung-Han Yoon ; Jin Seok Lee ; Yoonkey Nam ; Insung S. Choi
• 刊名：Nano Letters
• 出版年：2016
• 出版时间：January 13, 2016
• 年：2016
• 卷：16
• 期：1
• 页码：675-680
• 全文大小：388K
• ISSN：1530-6992

文摘

In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.