Microfluidic Synthesis of Hybrid Nanoparticles with Controlled Lipid Layers: Understanding Flexibility-Regulated Cell鈥揘anoparticle Interaction

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• 作者：Lu Zhang ; Qiang Feng ; Jiuling Wang ; Shuai Zhang ; Baoquan Ding ; Yujie Wei ; Mingdong Dong ; Ji-Young Ryu ; Tae-Young Yoon ; Xinghua Shi ; Jiashu Sun ; Xingyu Jiang
• 刊名：ACS Nano
• 出版年：2015
• 出版时间：October 27, 2015
• 年：2015
• 卷：9
• 期：10
• 页码：9912-9921
• 全文大小：659K
• ISSN：1936-086X

文摘

The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell鈥損article interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell鈥損article interaction may have important implications for designing drug nanocarriers.