Facile Construction of Multifunctional Nanocarriers Using Sequential Click Chemistry for Applications in Biology

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• 作者：Anjali Sharma ; Kevin Neibert ; Rishi Sharma ; Rami Hourani ; Dusica Maysinger ; Ashok Kakkar
• 刊名：Macromolecules
• 出版年：2011
• 出版时间：February 8, 2011
• 年：2011
• 卷：44
• 期：3
• 页码：521-529
• 全文大小：966K
• 年卷期：v.44,no.3(February 8, 2011)
• ISSN：1520-5835

文摘

Bi- and trifunctional dendrimer and miktoarm nanocarriers, containing a combination of covalently linked model drug (伪-lipoic acid), fluorescent dye (BODIPY), and poly(ethylene glycol) (PEG), are synthesized using a core with orthogonal functional groups, on which Huisgen alkyne鈭抋zide 鈥渃lick鈥?reactions are performed in sequence. These carriers are internalized into the cells where they reduce H₂O₂ induced reactive oxygen species formation. In addition, miktoarm nanocarriers conjugated with 伪-lipoic acid enhance intracellular glutathione (GSH) concentrations.