Use of 蠅-Transaminase Enzyme Chemistry in the Synthesis of a JAK2 Kinase Inhibitor

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• 作者：Lianne Frodsham ; Michael Golden ; Susan Hard ; Martin N. Kenworthy ; David J. Klauber ; Kevin Leslie ; Claire Macleod ; Rebecca E. Meadows ; Keith R. Mulholland ; Julie Reilly ; Christopher Squire ; Simone Tomasi ; Denise Watt ; Andrew S. Wells
• 刊名：Organic Process Research & Development
• 出版年：2013
• 出版时间：September 20, 2013
• 年：2013
• 卷：17
• 期：9
• 页码：1123-1130
• 全文大小：339K
• 年卷期：v.17,no.9(September 20, 2013)
• ISSN：1520-586X

文摘

蠅-Transaminase enzyme chemistry provides an excellent methodology to build synthetically useful chiral amines from their corresponding ketones. An application of this methodology, providing a long-term commercial manufacturing route to a JAK2 kinase inhibitor, is reported herein.