Sonochemical Synthesis of Hydrophilic Drug Loaded Multifunctional Bovine Serum Albumin Nanocapsules

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• 作者：Zhanfeng Li ; Ting Yang ; Chunming Lin ; Quanshun Li ; Songfeng Liu ; Fengzhi Xu ; Hongyan Wang ; Xuejun Cui
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：September 2, 2015
• 年：2015
• 卷：7
• 期：34
• 页码：19390-19397
• 全文大小：536K
• ISSN：1944-8252

文摘

A facile sonochemical approach is designed to fabricate protein nanocapsules for hydrophilic drugs (HDs), and HD-loaded multifunctional bovine serum albumin (BSA) nanocapsules (MBNCs) have been prepared for the first time. The as-synthesized HD-loaded MBNCs have a satisfying size range and an excellent magnetic responsive ability. Moreover, high-dose hydrophilic drugs could be loaded into the MBNCs. As carriers, HD-loaded MBNCs also show attractive redox-responsive controlled release ability for hydrophilic drugs and could be internalized selectively by the tumor cells through the folate-mediated endocytosis.