Inhibition of Endothelial Cell-Mediated Oxidation of Low-Density Lipoprotein by Rosemary and Plant Phenolics

详细信息    查看全文

• 作者：Debra A. Pearson ; Edwin N. Frankel ; Robert Aeschbach ; and J. Bruce German
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：1997
• 出版时间：March 1997
• 年：1997
• 卷：45
• 期：3
• 页码：578 - 582
• 全文大小：201K
• 年卷期：v.45,no.3(March 1997)
• ISSN：1520-5118

文摘

Plant-derived phenolic compounds possess antioxidant activity that maybe applicable to such diverseareas as human health and the preservation of food lipids. Thepotential antioxidant activities ofa variety of plant phenolics were investigated using human aorticendothelial cells (HAEC) to mediatethe oxidation of low-density lipoprotein (LDL). Carnosic acid,carnosol, and rosmarinic acid, presentin rosemary extract, and thymol, carvacrol, and zingerone, present inthyme, origanum, and ginger,were individually incubated with HAEC and LDL for 12 h. The extentof oxidation was determinedspectrophotometrically by measuring absorbance (at 234 nm) ofconjugated dienes. All antioxidantsproduced dose-dependent inhibition of LDL oxidation. Theirrelative antioxidant activities decreasedin the order carnosol > carnosic acid rosmarinic acid >>>thymol > carvacrol > zingerone. Theantioxidant activity of these plant phenolics in the HAEC systemsuggests that they may havepotential benefits in human health.Keywords: LDL oxidation; rosemary; plant phenolics; human aorticendothelial cells; antioxidants