Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A

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• 作者：Zhengxi Hu ; Ye Wu ; Shuangshuang Xie ; Weiguang Sun ; Yi Guo ; Xiao-Nian Li ; Junjun Liu ; Hua Li ; Jianping Wang ; Zengwei Luo ; Yongbo XueYonghui Zhang
• 刊名：Organic Letters
• 出版年：2017
• 出版时间：January 6, 2017
• 年：2017
• 卷：19
• 期：1
• 页码：258-261
• 全文大小：354K
• ISSN：1523-7052

文摘

Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of spectroscopic data, a modified Mosher’s method, X-ray crystallographic analysis, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a rearranged bicyclo[3.3.1]nonane motif resulting from B-ring scission and a subsequent 180° rotation of the ring A during biosynthesis. Compound 2 exhibited anti-inflammatory activity.