Asymmetric Desymmetrization of 1,3-Diketones via Intramolecular Benzoin Reaction

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• 作者：Yuanzhen Li ; Shuang Yang ; Genfa Wen ; Qiqiao Lin ; Guoxiang Zhang ; Lin Qiu ; Xiaoyan Zhang ; Guangfen Du ; Xinqiang Fang
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 1, 2016
• 年：2016
• 卷：81
• 期：7
• 页码：2763-2769
• 全文大小：466K
• ISSN：1520-6904

文摘

A general method for the asymmetric desymmetrization of 1,3-diketone substrates via chiral N-heterocyclic carbene catalyzed intramolecular benzoin reactions was developed. Five- and six-membered cyclic ketones bearing two contiguous fully substituted stereocenters were generated with excellent diastereoselectivities and moderate to excellent enantioselectivities.