Transition-Metal-Free Synthesis of Benzimidazoles Mediated by KOH/DMSO

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• 作者：Hannah Baars ; Astrid Beyer ; Stefanie V. Kohlhepp ; Carsten Bolm
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：536-539
• 全文大小：295K
• ISSN：1523-7052

文摘

Benzimidazoles are prepared by intramolecular N-arylations of amidines mediated by potassium hydroxide in DMSO at 120 掳C. In this manner, diversely substituted products have been obtained in moderate to very good yields.