Recognition and Stabilization of Peptide -Helices Using Templatable Nanoparticle Receptors

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• 作者：Ayush Verma ; Hiroshi Nakade ; Joseph M. Simard ; and Vincent M. Rotello
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：September 8, 2004
• 年：2004
• 卷：126
• 期：35
• 页码：10806 - 10807
• 全文大小：102K
• 年卷期：v.126,no.35(September 8, 2004)
• ISSN：1520-5126

文摘

-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.