Near-Infrared Dye-Conjugated Amphiphilic Hyaluronic Acid Derivatives as a Dual Contrast Agent for In Vivo Optical and Photoacoustic Tumor Imaging

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• 作者：Koji Miki ; Tatsuhiro Inoue ; Yasuhito Kobayashi ; Katsuya Nakano ; Hideki Matsuoka ; Fumio Yamauchi ; Tetsuya Yano ; Kouichi Ohe
• 刊名：Biomacromolecules
• 出版年：2015
• 出版时间：January 12, 2015
• 年：2015
• 卷：16
• 期：1
• 页码：219-227
• 全文大小：488K
• ISSN：1526-4602

文摘

Amphiphilic hyaluronic acid (HA) derivatives bearing hydrophobic indocyanine green dye derivatives and hydrophilic poly(ethylene glycol) were synthesized through the use of condensation and copper-catalyzed click cyclization reactions. The amphiphilic HA derivatives dissolved in water and formed self-assemblies in which the near-infrared dyes were tightly packed and arranged to form dimers or H-aggregates. By irradiating an aqueous solution of HA derivatives with near-infrared light, photoacoustic signals were detected along with fluorescence emission. Self-assemblies consisting of HA derivatives could smoothly accumulate in tumor tissues by passive tumor targeting. By utilizing HA derivatives as a contrast agent, tumor sites were clearly visualized by optical imaging as well as by photoacoustic tomography.