Fabrication and Characterization of Biodegradable Poly(3-hydroxybutyrate) Composite Containing Bioglass

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• 作者：Superb K. Misra ; Showan N. Nazhat ; Sabeel P. Valappil ; M. Moshrefi-Torbati ; Robert J. K. Wood ; Ipsita Roy ; Aldo R. Boccaccini
• 刊名：Biomacromolecules
• 出版年：2007
• 出版时间：July 2007
• 年：2007
• 卷：8
• 期：7
• 页码：2112 - 2119
• 全文大小：843K
• 年卷期：v.8,no.7(July 2007)
• ISSN：1526-4602

文摘

Bacterially derived poly(3-hydroxybutyrate) (P(3HB)) has been used to produce composite films by incorporatingBioglass particles (<5 m) in 5 and 20 wt % concentrations. P(3HB) was produced using a large scale fermentationtechnique. The polymer was extracted using the Soxhlet technique and was found to have similar thermal andstructural properties to the commercially available P(3HB). The effects of adding Bioglass on the microstructuresurface and thermal and mechanical properties were examined using differential scanning calorimetry, dynamicmechanical analysis (DMA), X-ray diffraction, surface interferometry, electron microscopy, and nanoindentation.The addition of increasing concentrations of Bioglass in the polymer matrix reduced the degree of crystallinityof the polymer as well as caused an increase in the glass transition temperature as determined by DMA. Thepresence of Bioglass particulates reduced the Young's modulus of the composite. The storage modulus and theloss modulus, however, increased with the addition of 20 wt % Bioglass. A short period (28 days) in vitro bioactivitystudy in simulated body fluid confirmed the bioactivity of the composites, demonstrated by the formation ofhydroxyapatite crystals on the composites' surface.