文摘
On the basis of the structure of natural product (鈭?-incrustoporin (1), a series of lactone compounds 4a鈥?b>i and 5a鈥?b>i were designed and synthesized from nitroolefin. The antiviral and antifungal activities of these compounds were evaluated in vitro and in vivo. The small changes between 4 and 5 at the 3,4-position result in large differences in bioactivities. Compounds 4 exhibited significantly higher antiviral activity against tobacco mosaic virus (TMV) than dehydro compounds 5. However, the antifungal activity of 4 is relatively lower than that of 5. Compounds 4a, 4c, and 4i with excellent in vivo anti-TMV activity emerged as new antiviral lead compounds. Compounds 5d鈥?b>g showed superiority over the commercial fungicides chlorothalonil and carbendazim against Cercospora arachidicola Hor at 50 mg kg鈥?. The present study provides fundamental support for the development and optimization of (鈭?-incrustoporin derivatives as potential inhibitors of plant virus and pathogenic fungi.
Keywords:
2,5-dihydrofuran-2-ones; (鈭?-incrustoporin derivatives; anti-TMV; antifungal activity
