Synergistic Rhodium/Copper Catalysis: Synthesis of 1,3-Enynes and N-Aryl Enaminones

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• 作者：Nan-Nan Wang ; Lei-Rong Huang ; Wen-Juan Hao ; Tian-Shu Zhang ; Guigen Li ; Shu-Jiang Tu ; Bo Jiang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1298-1301
• 全文大小：372K
• ISSN：1523-7052

文摘

Synergistic rhodium/copper catalysis enables new three-component coupling reactions of terminal alkynes and α-diazoketones and/or arylamines, allowing dediazotized carbene C–H insertion for the synthesis of functionalized 1,3-enynes and N-aryl enaminones with high stereoselectivity. The synthetic utility of these transformations results in subsequent C–C or/and C–N bond-forming reactions to effectively build up functional molecules with potential significance.