Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp.

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• 作者：Juanli Zhang ; Zhengyi Qian ; Xingkang Wu ; Yanjiao Ding ; Jianfang Li ; Chunhua Lu ; Yuemao Shen
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：May 16, 2014
• 年：2014
• 卷：16
• 期：10
• 页码：2752-2755
• 全文大小：271K
• 年卷期：v.16,no.10(May 16, 2014)
• ISSN：1523-7052

文摘

Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. This family has shown a high degree of druggability exemplified by rifamycins, maytansinoids, and geldanamycins. In this study, the isolation of two novel ansamycin macrodilactams with unprecedented features, juanlimycins A (1) and B (2), from Streptomyces sp. LC6 were reported. The structures of 1 and 2 were assigned on the basis of analysis of NMR spectroscopic data and X-ray single crystal diffraction.