Solid鈥揕iquid Equilibrium of d- and l-Tartaric Acid and Their Importance for Enantioseparation

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• 作者：Xiaofang Wang ; Xiangyang Zhang ; Simon Black ; Leping Dang ; Hongyuan Wei
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2012
• 出版时间：June 14, 2012
• 年：2012
• 卷：57
• 期：6
• 页码：1779-1786
• 全文大小：397K
• 年卷期：v.57,no.6(June 14, 2012)
• ISSN：1520-5134

文摘

The solid鈥搇iquid phase equilibrium of d- and l-tartaric acid (TA) was investigated in this work. Based on the solubility data, the dissolution enthalpy and entropy of the monohydrate racemic tartaric acid (race-TA) and enantiomer were calculated using van't Hoff plots. Binary melting point phase diagrams of d- and l-TA and ternary phase diagrams of d-TA/water/l-TA were also described. The results show that TA exhibits a racemic compound behavior. Furthermore, the influence of temperature on the eutectic points between enantiomer and racemic compounds was investigated. Finally, the importance of solid鈥搇iquid equilibrium on the purification and separation of enantiomers was discussed.