Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug鈥揇rug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

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Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug鈥揇rug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

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作者：Michael A. Brodney ; Elizabeth M. Beck ; Christopher R. Butler ; Gabriela Barreiro ; Eric F. Johnson ; David Riddell ; Kevin Parris ; Charles E. Nolan ; Ying Fan ; Kevin Atchison ; Cathleen Gonzales ; Ashley E. Robshaw ; Shawn D. Doran ; Mark W. Bundesmann ; Leanne Buzon ; Jason Dutra ; Kevin Henegar ; Erik LaChapelle ; Xinjun Hou ; Bruce N. Rogers ; Jayvardhan Pandit ; Ricardo Lira ; Luis Martinez-Alsina ; Peter Mikochik ; John C. Murray ; Kevin Ogilvie ; Loren Price ; Subas M. Sakya ; Aijia Yu ; Yong Zhang ; Brian T. O鈥橬eill
刊名：Journal of Medicinal Chemistry
出版年：2015
出版时间：April 9, 2015
年：2015
卷：58
期：7
页码：3223-3252
全文大小：1127K
ISSN：1520-4804

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